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19 substances

Beauty Industry & Med Spa

Botox parties, black-market filler, and the unregulated cosmetic procedures targeting under-25s. The beauty industry has a drug problem: unlicensed injectors, counterfeit Botox, illegal filler sold online, and teenagers getting lip filler at kitchen-table parties. These substances and procedures carry real risk — vascular occlusion, blindness, sepsis, and worse.

73%of FDA adverse-event reports for dermal fillers come from unlicensed/non-medical settings
19profiles in this category
Rx-only biologic

Botulinum Toxin (Botox)

Clear vials of freeze-dried toxin, reconstituted with saline; injected in units

Effects & risks →
Rx-only devices

Dermal Fillers (HA & Biostimulators)

Syringes/pre-filled pens of hyaluronic acid gel (Juvederm, Restylane) or biostimulators (Sculptra); or black-market filler vials sold online

Effects & risks →
Illegal for body contouring

Black-Market Silicone Injections

Industrial silicone oil or biopolymer gel injected at 'pumping parties' — hips, buttocks, breasts, lips

Effects & risks →
Rx-only enzyme

Hyaluronidase (Filler Dissolver)

Vials of enzyme powder, reconstituted to inject

Effects & risks →
Kybella FDA-approved

Fat-Dissolving Injections (Kybella & Copycats)

Injection vials of deoxycholic acid or phosphatidylcholine; injected into fat pockets

Effects & risks →
Unapproved everywhere — FDA warning letters; illegal to sell for human use

Melanotan (Tanning Injections)

Brownish powder vials reconstituted for injection; nasal sprays

Effects & risks →
Rx-only

Bimatoprost (Latisse / Lash Serums)

Eyeliner-style applicator bottles of prostaglandin solution

Effects & risks →
Unregulated device; FDA has warned against needle-free filler devices

Hyaluron Pen (DIY Filler Injector)

Pen-shaped spring-loaded device that force-sprays hyaluronic acid or other liquids into the skin — no needle, sold on marketplaces and social media

Effects & risks →
Unapproved use IV; oral supplement; injections restricted several countries

Glutathione IV (Skin-Whitening Drips)

IV bags or vials administered at 'drip bars', med spas, and salons — especially Southeast Asia, Africa, Caribbean; oral pills as weaker version

Effects & risks →
Rx-only device

PDO Thread Lifts (Non-Surgical Facelift)

Dissolvable barbed sutures inserted under the skin to lift jowls/brows; 'lunchtime facelift' at med spas

Effects & risks →
Rx procedure

PRP 'Vampire Facial' (Platelet-Rich Plasma)

Your own blood drawn, spun in a centrifuge, plasma injected or microneedled into the face

Effects & risks →
FDA-cleared device

Cryolipolysis (CoolSculpting / Fat Freezing)

Clinic paddles that freeze fat pockets (abdomen, chin); also sold as home 'fat freeze belts' and machines on marketplaces

Effects & risks →
Rx-only device US/EU

Poly-L-lactic Acid (Sculptra)

Vials of poly-L-lactic acid microspheres reconstituted with saline; injected over 2–3 sessions for gradual volume

Effects & risks →
Unapproved drug cocktails US

Mesotherapy (Injectable Cocktails)

Micro-injections of custom 'cocktails' — vitamins, enzymes, plant extracts, phosphatidylcholine — into fat or skin; also 'skin booster' hyaluronic microdroplets

Effects & risks →
Supplement oral; injections Rx/medical gray; IV bars unregulated

Biotin Injections & Hair IV Drips

IM/IV biotin, zinc, B-complex 'hair drips' at wellness bars; oral megadoses (10,000 mcg) everywhere

Effects & risks →
Professional plasma devices Rx-regulated; home pens unregulated marketplaces

Plasma Fibroblast Pens (DIY Skin Tightening)

Pen-like device creating tiny plasma burns ('carbon dots') on skin to tighten eyelids/neck; home versions sold on marketplaces for $40–$150

Effects & risks →
Off-label/unapproved for cosmetics US; medical use

Carboxytherapy (CO2 Injections)

Medical CO2 gas injected under skin to 'improve circulation' and reduce cellulite/stretch marks; offered at med spas

Effects & risks →
Cosmetic ingredient — unregulated

Syn-Ake & 'Snake Venom' Cosmetics

Anti-wrinkle creams with synthetic peptides mimicking waglerin-1 (temple viper venom) that 'freezes' mimic lines

Effects & risks →
Unlicensed

Apetamin (Unlicensed Weight-Gain Syrup)

Sweet syrup marketed on Instagram and TikTok for curves/weight gain; contains cyproheptadine, lysine, and vitamins.

Effects & risks →