Overdose or emergency? Call now Hotlines · US 911 · UK 999 · EU 112 · AU 000 · IN 112 · 988 (US crisis) Hotlines
50 substances

Cannabinoids

Natural cannabis and synthetic 'Spice' — same receptors, wildly different dangers. Natural cannabis is one of the most-used drugs on earth — low acute toxicity but real risks with potency, dependence and contaminants. Synthetic cannabinoids ('Spice', K2) bind far harder than THC: seizures, catatonia, kidney failure, deaths.

100x+potency of some synthetics vs natural THC
50profiles in this category
Schedule I

4F-ADB

White/yellow powder sprayed onto plant material ('K2/Spice') or in vape carts

Effects & risks →
Schedule I

5F-ADB / 5F-ADBICA

White powder sprayed on plant material or dissolved in e-liquid

Effects & risks →
Schedule I

JWH-250

White powder on plant material or in 'incense'

Effects & risks →
Analogue prosecutions

NM-2201 (CBL-2201)

Off-white powder sprayed on herbs or in vape liquid

Effects & risks →
Schedule I

Cannabis (Weed)

Dried green/brown flower buds; hash/resin; oils & wax (concentrates); edibles; vape cartridges

Effects & risks →
Schedule III

Dronabinol (Marinol)

Soft gelatin capsules (2.5/5/10 mg) in amber bottles

Effects & risks →
Schedule I

THC Vapes & Carts

510-thread cartridges (clear oil, various colors), disposable pens, pod systems; black-market carts often darker/thicker

Effects & risks →
Follows local cannabis law; unregulated market where illegal

Cannabis Edibles (THC/CBD)

Gummies, chocolates, baked goods, drinks; legal-market labeled dosing (5–10 mg), black-market often unlabeled or 50–100 mg+

Effects & risks →
Federally unscheduled

Delta-8 THC

Gummies, vapes, tinctures, flower sprayed with D8 distillate — sold at gas stations, smoke shops

Effects & risks →
Federally unscheduled; state bans spreading

HHC (Hexahydrocannabinol)

Vapes, gummies, distillate — semi-synthetic cannabinoid from hemp CBD

Effects & risks →
Federally unscheduled; DEA considers it illegal

THC-O Acetate

Vapes, gummies, tinctures — synthetic 'super THC'

Effects & risks →
Schedule I

K2 / Spice (Synthetic Cannabinoids)

Herbal material sprayed with synthetic cannabinoids — sold as 'incense', 'potpourri'; also vape carts and edibles

Effects & risks →
Schedule I analog; controlled EU

MDMB-CHMICA

Herbal blend sprayed with synthetic cannabinoid

Effects & risks →
Schedule I analog; controlled EU

PX-1 (5F-APP-PINACA)

Powder/herbal blend

Effects & risks →
Analog prosecution; controlled EU

ADB-B (Adamantyl carboxamide cannabinoid)

Powder/sprayed herb

Effects & risks →
Schedule I analog; controlled EU

SGT-263

Powder/sprayed herb

Effects & risks →
Analog prosecution; controlled EU

MPHP-2201

Powder/sprayed herb

Effects & risks →
Analog prosecution; controlled EU

EG-018

Powder/sprayed herb

Effects & risks →
Schedule I analog; controlled EU

FUB-AKB48 (FUB-APINACA)

Powder/sprayed herb

Effects & risks →
Analog prosecution; controlled EU

5C-AB-PINACA

Powder/sprayed herb

Effects & risks →
Schedule I analog; controlled EU

ADB-CHMINACA

Powder/sprayed herb

Effects & risks →
Analog prosecution; controlled EU

APP-CHMINACA

Powder/sprayed herb

Effects & risks →
Analog prosecution; controlled EU

AB-CHFUPPYCA

Powder/sprayed herb

Effects & risks →
Schedule I analog; controlled EU

MDMB-FUBINACA

Powder/sprayed herb — potent indazole cannabinoid

Effects & risks →
Follows local cannabis law; unregulated where illegal

Rick Simpson Oil (RSO / Phoenix Tears)

Dark black/brown thick cannabis extract; sold in syringes

Effects & risks →
Follows cannabis law; concentrates felony in some prohibition states

Dabs / Shatter / Wax (THC Concentrates)

Amber glass-like shatter, waxy crumble, sticky live resin; vaporized on hot nails

Effects & risks →
Federally legal US

CBD Flower / Hemp Bud

Looks/smells identical to cannabis flower — legal-sale grey zone

Effects & risks →
Unregulated; derived from aged THC

CBN (Cannabinol)

Oils, gummies, vapes marketed for sleep

Effects & risks →
Federally unscheduled; DEA gray; banned several states

THC-P (Tetrahydrocannabiphorol)

Vapes, gummies — semi-synthetic 'super THC'

Effects & risks →
Federally unscheduled; state bans spreading

THC-B (Tetrahydrocannabutol)

Vapes/gummies — butyl homolog of THC

Effects & risks →
Federally unscheduled; banned some states

Delta-10 THC

Vapes/gummies — minor cannabinoid, often synthetic-ish production

Effects & risks →
Federally unscheduled; banned some states

HHCP (Hexahydrocannabiphorol)

Vapes/gummies — hydrogenated THCP

Effects & risks →
Federally unscheduled; DEA gray; banned some states

Delta-8-THC-O-Acetate

Vapes — acetylated Delta-8

Effects & risks →
Federally unscheduled; banned some states

Delta-10-THC-O-Acetate

Vapes

Effects & risks →
Unregulated research cannabinoid

CBND (Cannabinodiol)

Research-grade only

Effects & risks →
Federally unscheduled; banned some states

Delta-6a10a THC

Vapes — positional isomer

Effects & risks →
Follows cannabis law; illegal most of Africa/Asia/Middle East where it's most consumed

Hashish (Cannabis Resin)

Dark brown/black resin blocks (Afghan/Moroccan), soft 'pollen' powder; smoked, eaten, or in tea

Effects & risks →
Federally unscheduled

THCA Flower (The 'Legal Weed' Loophole)

Identical-looking cannabis flower sold in smoke shops and online as 'hemp'; converts to Delta-9 THC when heated

Effects & risks →
Hemp-derived

THCjd

Vape cartridges, gummies and distillate sold in smoke shops and online; usually blended with HHC or Delta-8

Effects & risks →
Hemp-derived gray zone — state bans spreading; zero safety data

THCh

Vape carts, disposables and gummies; almost always blended with HHC, THCP or Delta-8

Effects & risks →
Hemp-derived gray zone — state bans spreading

HHC-O (HHC Acetate)

Vape carts and disposables; golden distillate, thicker than HHC

Effects & risks →
Schedule I

JWH-018

Sprayed onto herbal smoking blends — the original 'Spice' ingredient

Effects & risks →
Schedule I

UR-144

Sprayed on herbal blends; second-generation spice ingredient

Effects & risks →
Schedule I

AM-2201

Sprayed on herbal smoking blends

Effects & risks →
Schedule I

XLR-11 (5F-UR-144)

Sprayed on herbal blends; notorious 2012–13 'spice' wave ingredient

Effects & risks →
Schedule I

5F-ADB (5F-MDMB-PINACA)

Sprayed on plant material or soaked into paper — dominant prison 'spice' chemical

Effects & risks →
Schedule I

AMB-FUBINACA

Sprayed on plant material; caused the 2016 Brooklyn 'zombie' mass overdose

Effects & risks →
Schedule I

AB-FUBINACA

Sprayed on herbal blends

Effects & risks →
Schedule I

MDMB-4en-PINACA

Current-generation spice chemical sprayed on plant material and paper

Effects & risks →
Hemp-derived; legal under 2018 Farm Bill

CBG (Cannabigerol)

Hemp flower, oils and gummies marketed for focus and gut health

Effects & risks →