Beauty Industry & Med Spa

Hyaluronidase (Filler Dissolver)

Street names: Hyalase, Vitrase, Hylenex, Filler eraser

Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines

⚡What it does

Dissolves hyaluronic-acid filler within hours — the 'undo button' for HA fillers
Spreads injected drugs (historical medical use)

Allergic reactions including anaphylaxis — must be available at any filler appointment
Over-dissolution: removes your OWN hyaluronic acid — temporary hollowing/deflation
Does NOT work on biostimulators (Sculptra) or silicone — irreversible fillers have no undo
Black-market injectors don't stock it — occlusion without hyaluronidase = necrosis/blindness

Also known asHyalase, Vitrase, Hylenex, Filler eraser

CategoryBeauty Industry & Med Spa

Schedule / classRx-only enzyme

AppearanceVials of enzyme powder, reconstituted to inject

Street price$50–$150 per vial (clinic cost)

Legal statusRx-only; the reason any legitimate filler clinic must have a licensed prescriber present

Last updated2026-09-17

Sources: FDA, EMA

Substance	Class	Top risks	Street price
Hyaluronidase (Filler Dissolver)	Rx-only enzyme	Allergic reactions including anaphylaxis — must be available at any filler appointment; Over-dissolution: removes your OWN hyaluronic acid — temporary hollowing/deflation	$50–$150 per vial
Dermal Fillers (HA & Biostimulators)	Rx-only devices	VASCULAR OCCLUSION — the big one: filler injected into an artery blocks blood flow → skin necrosis (black dying skin) or BLINDNESS (filler migrating to eye artery; ~300+ documented cases); Unlicensed injector + no hyaluronidase on hand = occlusion becomes catastrophe	Legit: $500–$2,000 per syringe
Botulinum Toxin (Botox)	Rx-only biologic	BLACK-MARKET BOTOX: counterfeit vials, overdosed units, and fake 'Botox parties' cause drooping, asymmetry, swallowing/breathing difficulty; Injection into wrong muscle: eyelid ptosis (drooping eye), uneven smile — lasts weeks-months	Legit: $10–$15 per unit

Street prices are regional estimates. Potency and cuts vary constantly.

What does Hyaluronidase (Filler Dissolver) look like?

Vials of enzyme powder, reconstituted to inject

What are the signs of a Hyaluronidase (Filler Dissolver) overdose?

Allergic reaction: hives, swelling, difficulty breathing; Excessive tissue dissolution Call emergency services immediately.

How addictive is it?

Allergic reactions including anaphylaxis — must be available at any filler appointment Dependence can develop with regular use.

Facts on this page are compiled from these primary sources. External links open in a new tab.