GHB/GBL + Ketamine
GHB/GBL + Ketamine: the short answerBoth drugs can individually knock you out; together the risk of deep unconsciousness, vomiting, and airway blockage rises sharply. Anyone who cannot be fully woken needs the recovery position and an emergency call.
Why it’s dangerous
GHB is a GABA-B sedative with a steep dose curve, and ketamine is a dissociative anesthetic that causes immobility and, at higher doses, unresponsiveness. Combined, they produce much deeper and longer unconsciousness than expected, and ketamine's tendency to cause nausea plus GHB's vomiting means the airway is at real risk while the person cannot move or wake.
What happens
- Sudden, deep unresponsiveness — neither drug can be 'talked down'
- Nausea and vomiting while immobile or unconscious
- Breathing that is slow or irregular
- Long, confused recovery with no memory of events
Warning signs
- Unrousable or only partially responsive
- Choking, gurgling, or vomit in the airway
- Breathing pauses or blue-tinged lips
What to do
- Call emergency services for anyone you cannot keep awake
- Recovery position immediately; keep the airway clear of vomit
- Stay with them — GHB overdoses can worsen after a brief improvement
- Never use this combination alone, and avoid redosing either drug the same night