Hazardous Substances
Cyclizine (Marzine / Valoid)
Street names: Marzine, Marezine, Valoid, The methadone potentiater
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Antihistamine-anticholinergic: sedation, mild dissociation at high doses; potentiates opioids
⚠Key risks
- THE UK INJECTING SCENE: cyclizine crushed and injected with methadone ('the blue and white') — severe tissue damage, abscesses, and the combination deepens respiratory depression
- Anticholinergic load at high doses — delirium
- OTC accessibility; cheap
- Also misused as a cheap sedative in prisons
✚Overdose signs
- Sedation + anticholinergic signs (dry, racing heart)
- Respiratory depression with opioids
Category comparison — Hazardous Substances
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Cyclizine (Marzine / Valoid) | OTC/Rx travel-sickness tablets most countries | THE UK INJECTING SCENE: cyclizine crushed and injected with methadone ('the blue and white') — severe tissue damage, abscesses, and the combination deepens respiratory depression; Anticholinergic load at high doses — delirium | ~$0.10–$0.50 per tablet OTC |
| Potassium Cyanide (KCN) | Not a drug — regulated toxic chemical | Lethal dose ~200–300 mg — death within minutes to an hour; No antidote available outside hospital; hydrogen cyanide gas from acid contact | N/A — sometimes sold fraudulently as 'peaceful exit' scams |
| Air Duster (Computer Duster / Canned Air) | Household product — not a drug; no age restriction on purchase | SUDDEN SNIFFING DEATH — the most deadly inhalant: difluoroethane sensitizes the heart to adrenaline; a sudden fright, chase, or exertion triggers fatal cardiac arrest. First-time users die; Frostbite to lungs and airway from direct spray | $3–$8 per can at any electronics/office store |
| Gasoline / Petrol Huffing | Not a drug — fuel product | Extremely toxic hydrocarbons (benzene, toluene, xylene); Sudden sniffing death — cardiac arrest | Effectively free — siphoned fuel |
| Glue / Solvent Sniffing | Not drugs — adhesives and solvents | The CLASSIC youth inhalant — peak use age 14–15; Sudden sniffing death from cardiac arrest | $1–$5 per tube/can — pocket money prices |
| Refrigerant / Freon Huffing | Not a drug — HVAC refrigerant | EXTREMELY dangerous — refrigerant gases (difluoroethane, tetrafluoroethane) cause sudden cardiac death at high rates; Frostbite to airways | Stolen/siphoned — no price, high death cost |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Cyclizine (Marzine / Valoid) look like?
50 mg tablets; UK: injected with methadone in the 'cyclizine' scene
What are the signs of a Cyclizine (Marzine / Valoid) overdose?
Sedation + anticholinergic signs (dry, racing heart); Respiratory depression with opioids Call emergency services immediately.
How addictive is it?
THE UK INJECTING SCENE: cyclizine crushed and injected with methadone ('the blue and white') — severe tissue damage, abscesses, and the combination deepens respiratory depression Dependence can develop with regular use.