Hazardous Substances
Cyclizine (Marzine / Valoid)
Street names: Marzine, Marezine, Valoid, The methadone potentiater
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Antihistamine-anticholinergic: sedation, mild dissociation at high doses; potentiates opioids
⚠Key risks
- THE UK INJECTING SCENE: cyclizine crushed and injected with methadone ('the blue and white') — severe tissue damage, abscesses, and the combination deepens respiratory depression
- Anticholinergic load at high doses — delirium
- OTC accessibility; cheap
- Also misused as a cheap sedative in prisons
✚Overdose signs
- Sedation + anticholinergic signs (dry, racing heart)
- Respiratory depression with opioids
📋Quick facts
Also known asMarzine, Marezine, Valoid, The methadone potentiater
CategoryHazardous Substances
Schedule / classOTC/Rx travel-sickness tablets most countries
Appearance50 mg tablets; UK: injected with methadone in the 'cyclizine' scene
Street price~$0.10–$0.50 per tablet OTC
Legal statusOTC/Rx; unscheduled; pharmacy-diversion documented UK/NZ
Last updated2026-09-18
Sources: NHS, EMCDDA
Category comparison — Hazardous Substances
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Cyclizine (Marzine / Valoid) | OTC/Rx travel-sickness tablets most countries | THE UK INJECTING SCENE: cyclizine crushed and injected with methadone ('the blue and white') — severe tissue damage, abscesses, and the combination deepens respiratory depression; Anticholinergic load at high doses — delirium | ~$0.10–$0.50 per tablet OTC |
| Promethazine (Phenergan) | Rx US; OTC UK/EU | THE LEAN MULTIPLIER: promethazine deepens codeine's respiratory depression — the combination in purple drank is part of why it kills; IV promethazine: severe tissue necrosis (the famous black-box warning) | ~$0.20–$1 per tablet |
| Methadone | Schedule II | Accumulates over days — overdose risk highest in first 2 weeks; Fatal mixing with benzos/alcohol | ~$10–$40 per 40 mg diskette |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Cyclizine (Marzine / Valoid) look like?
50 mg tablets; UK: injected with methadone in the 'cyclizine' scene
What are the signs of a Cyclizine (Marzine / Valoid) overdose?
Sedation + anticholinergic signs (dry, racing heart); Respiratory depression with opioids Call emergency services immediately.
How addictive is it?
THE UK INJECTING SCENE: cyclizine crushed and injected with methadone ('the blue and white') — severe tissue damage, abscesses, and the combination deepens respiratory depression Dependence can develop with regular use.