Opioids
Diphenoxylate (Lomotil)
Street names: Lomotil, Diphenoxylate-atropine
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Opioid antidiarrheal — the poor cousin of loperamide, with the same mega-dose abuse pattern
⚠Key risks
- THE ATROPINE TRAP: high doses mean high atropine — anticholinergic delirium ON TOP of opioid effects; users chasing the opioid get the toxidrome
- Respiratory depression
- Cheap and OTC-ish (Rx but loosely held)
✚Overdose signs
- Delirium + sedation (both toxidromes at once)
- Slow breathing
- Racing heart, dry skin
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Diphenoxylate (Lomotil) | Schedule V | THE ATROPINE TRAP: high doses mean high atropine — anticholinergic delirium ON TOP of opioid effects; users chasing the opioid get the toxidrome; Respiratory depression | ~$0.20–$0.50 per tablet |
| Heroin | Schedule I | Extremely addictive — physical dependence in weeks; Overdose: breathing slows or stops | ~$10–$40 per bag |
| Fentanyl | Schedule II | Respiratory depression; Addiction in days | ~$20–$40 per counterfeit pill |
| Fentanyl HCl (powder) | Schedule II / analogue prosecutions | Lab-purity powder is far stronger than street mixes; Weighing errors are fatal | ~$60–$120/gram wholesale equivalent |
| Acetylfentanyl | Schedule I | ~5–15× weaker than fentanyl but still deadly at gram-level mistakes; Frequent cause of cluster overdoses | ~$25–$60/g where found |
| Furanylfentanyl (Fu-F) | Schedule I | Linked to hundreds of fatal overdoses 2016–2018; Potency similar to fentanyl | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Diphenoxylate (Lomotil) look like?
2.5 mg tablets combined with atropine (0.025 mg) — the atropine is the abuse-deterrent
What are the signs of a Diphenoxylate (Lomotil) overdose?
Delirium + sedation (both toxidromes at once); Slow breathing; Racing heart, dry skin Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.
How addictive is it?
THE ATROPINE TRAP: high doses mean high atropine — anticholinergic delirium ON TOP of opioid effects; users chasing the opioid get the toxidrome Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.