Dissociatives
Esketamine (Spravato)
Street names: Spravato, S-ketamine, Esket
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- The S-enantiomer of ketamine as an antidepressant: rapid (hours-days) relief for treatment-resistant depression
- Clinic-supervised dissociation per session
⚠Key risks
- Clinic-only for a reason: BP spikes, dissociation requiring monitoring
- Abuse/diversion liability — that's why it's REMS-locked
- Bladder harm with the repeated dosing schedule (2x/week initiation)
- Street 'S-isomer ketamine' claims — mostly marketing
- Not a take-home party drug; black-market 'Spravato' is counterfeit
✚Overdose signs
- Severe dissociation/panic
- Hypertensive crisis signs
- Sedation
Category comparison — Dissociatives
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Esketamine (Spravato) | Schedule III | Clinic-only for a reason: BP spikes, dissociation requiring monitoring; Abuse/diversion liability — that's why it's REMS-locked | Clinic course $4,700–$6,800 first month US |
| Ketamine | Schedule III | Bladder damage (ketamine cystitis) with regular use; K-holes and accidents while impaired | ~$20–$60 per gram |
| Ketalar (ketamine injection) | Schedule III | IV use raises infection and dependence risk; Bladder harm identical to powder use | ~$30–$100 per vial |
| 2F-DCK (2-fluorodeschloroketamine) | Analogue prosecutions | Very little human safety data; Bladder toxicity assumed similar to ketamine | ~$25–$60 per gram |
| DXM (Dextromethorphan / Robotripping) | OTC | Serotonin syndrome — DXM is serotonergic; DEADLY with SSRIs, MAOIs, MDMA; Liver damage — Coricidin contains chlorpheniramine (antihistamine) that's hepatotoxic at abuse doses | ~$5–$12 per bottle |
| 3-MeO-PCP | Analog prosecution | MANIA and dangerous disinhibition — users hurt themselves/others; Overdose: severe dissociation, catatonia | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Esketamine (Spravato) look like?
28 mg or 56 mg intranasal spray devices; clinic-administered only (REMS program)
What are the signs of a Esketamine (Spravato) overdose?
Severe dissociation/panic; Hypertensive crisis signs; Sedation Call emergency services immediately.
How addictive is it?
Clinic-only for a reason: BP spikes, dissociation requiring monitoring Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.