Opioids
Isotodesnitazene
Street names: Iso, ISO
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Euphoria, heavy sedation — nitazene-class opioid
⚠Key risks
- Fentanyl-level or greater potency
- Driving a new wave of overdose clusters since 2022
✚Overdose signs
- Pinpoint pupils
- Slow breathing
- Blue lips
📋Quick facts
Also known asIso, ISO
CategoryOpioids
Schedule / classEmerging — prosecuted as analogue (US); banned in several EU states
AppearanceWhite/yellow powder, often mixed into heroin or counterfeit pills
Street price~$30–$70/g where found
Legal statusAnalogue Act prosecutions (US); scheduled in DE/UK/others — check locally
Last updated2026-09-12
Sources: EMCDDA, DEA, NPS-AD
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Isotodesnitazene | Emerging — prosecuted as analogue | Fentanyl-level or greater potency; Driving a new wave of overdose clusters since 2022 | ~$30–$70/g where found |
| Etonitazene | Schedule I | ~10–25× fentanyl potency; Active at sub-milligram doses — nearly impossible to dose safely | ~$40–$100/g |
| Fentanyl | Schedule II | Respiratory depression; Addiction in days | ~$20–$40 per counterfeit pill |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Isotodesnitazene look like?
White/yellow powder, often mixed into heroin or counterfeit pills
What are the signs of a Isotodesnitazene overdose?
Pinpoint pupils; Slow breathing; Blue lips Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.
How addictive is it?
Fentanyl-level or greater potency Dependence can develop with regular use.