Cannabinoids
JWH-018
Street names: JWH-018, 1-pentyl-3-(1-naphthoyl)indole, Original Spice chemical
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- THC-like high, often stronger and shorter
- Sedation at high doses
⚠Key risks
- Full CB1 agonist — unlike THC it can cause seizures and psychosis outright
- Drove the first wave of synthetic-cannabinoid ER visits
- Still detected in prison 'spice' papers
✚Overdose signs
- Seizures
- Agitation, psychosis
- Racing heart, vomiting
Category comparison — Cannabinoids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| JWH-018 | Schedule I | Full CB1 agonist — unlike THC it can cause seizures and psychosis outright; Drove the first wave of synthetic-cannabinoid ER visits | Included in spice products ~$5–$20/pack |
| 4F-ADB | Schedule I | Associated with 'Spice zombies' — catatonia, seizures; Unpredictable potency sprayed unevenly | ~$5–$20 per gram of 'herbal blend' |
| 5F-ADB / 5F-ADBICA | Schedule I | Multiple deaths linked to 5F-ADB (the compound behind early 'zombie spice' outbreaks); Seizures, kidney injury | ~$5–$20 per gram of blend |
| JWH-250 | Schedule I | First-generation spice compound; contaminated batches caused outbreaks; Anxiety, tachycardia | ~$5–$15 per gram of blend |
| NM-2201 (CBL-2201) | Analogue prosecutions | Little human data; Severe anxiety, seizures reported | ~$5–$20 per gram of blend |
| Cannabis (Weed) | Schedule I | Anxiety, panic attacks, paranoia — especially high-THC strains and concentrates; Impaired memory, coordination and driving ability for hours | ~$10–$20 per gram flower |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does JWH-018 look like?
Sprayed onto herbal smoking blends — the original 'Spice' ingredient
What are the signs of a JWH-018 overdose?
Seizures; Agitation, psychosis; Racing heart, vomiting Call emergency services immediately.
How addictive is it?
Full CB1 agonist — unlike THC it can cause seizures and psychosis outright Dependence can develop with regular use.