Sedatives & Hypnotics
Lofexidine (Lucemyra)
Street names: Lucemyra, Lofexidine, The official detox pill
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Alpha-2 agonist made specifically for opioid withdrawal — FDA-approved 2018; calms the noradrenaline storm behind agitation, sweating, cramps and insomnia
- Reduces withdrawal symptoms; it does NOT treat cravings the way buprenorphine or methadone do
- Same family as clonidine but dosed and studied for detox
⚠Key risks
- Lowers blood pressure and slows the heart — fainting and falls, especially with dehydration from withdrawal vomiting/diarrhea
- QT prolongation (heart rhythm) at higher doses — caution with methadone or other QT drugs
- Rebound blood-pressure spike if stopped abruptly; treats symptoms, not addiction itself
✚Overdose signs
- Fainting, very slow pulse, dizziness on standing, severe drowsiness
- Collapse — call emergency services; hospital admission for monitored detox is safer
Category comparison — Sedatives & Hypnotics
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Lofexidine (Lucemyra) | Rx-only — not a controlled substance | Lowers blood pressure and slows the heart — fainting and falls, especially with dehydration from withdrawal vomiting/diarrhea; QT prolongation (heart rhythm) at higher doses — caution with methadone or other QT drugs | ~$10–15 per tablet retail |
| Zolpidem (Ambien/Stilnox) | Schedule IV | Sleep-walking, sleep-driving, hallucinations; Dependence and rebound insomnia | ~$2–$10 per 10 mg tablet |
| Secobarbital (Seconal) | Schedule II | Barbiturates: tiny margin between dose and death; Fatal in overdose, brutal withdrawal (seizures) — replaced by benzos in medicine | ~$15–$40 per capsule where diverted |
| Carisoprodol (Soma) | Schedule IV | Converts to meprobamate (Miltown) — dependence; Popular 'Soma Coma' mix with opioids — deadly | ~$1–$8 per 350 mg tablet |
| Cyclobenzaprine (Flexeril) | Not scheduled | Overdose causes hallucinations, seizures, heart rhythm problems; Abuse usually in combination (potentiates opioids) | ~$1–$5 per 10 mg tablet |
| Pentobarbital (Nembutal) | Schedule II | Veterinary euthanasia drug — overdose is usually fatal; Narrow safety margin (barbiturate) | ~$30–$100+ per vial/capsule-equivalent |
Street prices are regional estimates. Potency and cuts vary constantly.
RxBrand names on the grey market
These brands are sold as this compound. Same molecule, different label and supply chain — quality varies enormously between them.
Lucemyra
?Frequently asked questions
What does Lofexidine (Lucemyra) look like?
0.18 mg tablets; taken up to 4× daily during withdrawal
What are the signs of a Lofexidine (Lucemyra) overdose?
Fainting, very slow pulse, dizziness on standing, severe drowsiness; Collapse — call emergency services; hospital admission for monitored detox is safer Call emergency services immediately.
How addictive is it?
Lowers blood pressure and slows the heart — fainting and falls, especially with dehydration from withdrawal vomiting/diarrhea Dependence can develop with regular use.