Dissociatives
Methoxetamine (MXE)
Street names: MXE, Mexxy, Roffle
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- 2010–2013's 'legal ketamine': warmer, longer (3–5 h), more euphoric dissociation
⚠Key risks
- The original MXE wave showed bladder harm, dependence, and dissociative-panic hospitalizations
- Banned nearly everywhere by 2016 — remaining supply is grey/unknown
- Sold as 'ketamine' or '2F-DCK' mislabel
- Psychosis with binges
✚Overdose signs
- Heavy dissociative sedation
- Panic, paranoia
- Bladder symptoms with chronic use
Category comparison — Dissociatives
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Methoxetamine (MXE) | Analogue prosecutions | The original MXE wave showed bladder harm, dependence, and dissociative-panic hospitalizations; Banned nearly everywhere by 2016 — remaining supply is grey/unknown | Residual |
| Ketamine | Schedule III | Bladder damage (ketamine cystitis) with regular use; K-holes and accidents while impaired | ~$20–$60 per gram |
| Ketalar (ketamine injection) | Schedule III | IV use raises infection and dependence risk; Bladder harm identical to powder use | ~$30–$100 per vial |
| 2F-DCK (2-fluorodeschloroketamine) | Analogue prosecutions | Very little human safety data; Bladder toxicity assumed similar to ketamine | ~$25–$60 per gram |
| DXM (Dextromethorphan / Robotripping) | OTC | Serotonin syndrome — DXM is serotonergic; DEADLY with SSRIs, MAOIs, MDMA; Liver damage — Coricidin contains chlorpheniramine (antihistamine) that's hepatotoxic at abuse doses | ~$5–$12 per bottle |
| 3-MeO-PCP | Analog prosecution | MANIA and dangerous disinhibition — users hurt themselves/others; Overdose: severe dissociation, catatonia | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Methoxetamine (MXE) look like?
White/off-white powder; sublingual/intranasal/oral
What are the signs of a Methoxetamine (MXE) overdose?
Heavy dissociative sedation; Panic, paranoia; Bladder symptoms with chronic use Call emergency services immediately.
How addictive is it?
The original MXE wave showed bladder harm, dependence, and dissociative-panic hospitalizations Dependence can develop with regular use.