Dissociatives
Methoxetamine (MXE)
Street names: MXE, Mexxy, Roffle
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- 2010–2013's 'legal ketamine': warmer, longer (3–5 h), more euphoric dissociation
⚠Key risks
- The original MXE wave showed bladder harm, dependence, and dissociative-panic hospitalizations
- Banned nearly everywhere by 2016 — remaining supply is grey/unknown
- Sold as 'ketamine' or '2F-DCK' mislabel
- Psychosis with binges
✚Overdose signs
- Heavy dissociative sedation
- Panic, paranoia
- Bladder symptoms with chronic use
📋Quick facts
Also known asMXE, Mexxy, Roffle
CategoryDissociatives
Schedule / classAnalogue prosecutions (US); Class B UK; controlled EU
AppearanceWhite/off-white powder; sublingual/intranasal/oral
Street priceResidual; $25–$60/g when found
Legal statusControlled UK/EU/China; analogue US
Last updated2026-09-18
Sources: EMCDDA, NIDA
Category comparison — Dissociatives
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Methoxetamine (MXE) | Analogue prosecutions | The original MXE wave showed bladder harm, dependence, and dissociative-panic hospitalizations; Banned nearly everywhere by 2016 — remaining supply is grey/unknown | Residual |
| Ketamine | Schedule III | Bladder damage (ketamine cystitis) with regular use; K-holes and accidents while impaired | ~$20–$60 per gram |
| Arylcyclohexylamine RCs (3-HO-PCP, 3-MeO-PCE, DCK, O-PCE) | Analogue prosecutions | MANIA + dangerous disinhibition (3-HO-PCP especially): users hurt themselves while detached; Functional dissociation — appear sober, drive impaired | ~$25–$60/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Methoxetamine (MXE) look like?
White/off-white powder; sublingual/intranasal/oral
What are the signs of a Methoxetamine (MXE) overdose?
Heavy dissociative sedation; Panic, paranoia; Bladder symptoms with chronic use Call emergency services immediately.
How addictive is it?
The original MXE wave showed bladder harm, dependence, and dissociative-panic hospitalizations Dependence can develop with regular use.