Opioids
Mitragynine (Kratom's Main Alkaloid)
Street names: Mitragynine, Kratom alkaloid, MG
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- The main active alkaloid of kratom — a partial mu-opioid agonist plus stimulant-like adrenergic activity
- Low doses: alertness, sociability (coffee-like); high doses: opioid-like sedation and pain relief
- Weaker than 7-hydroxymitragynine (7-OH), which the body converts it into — but extracts concentrate the conversion
⚠Key risks
- Dependence and withdrawal are real: daily use builds a habit with opioid-type withdrawal (restless legs, anxiety, cravings)
- Potentiates other sedatives; dangerous with alcohol, benzos and opioids
- Rare but documented liver injury with regular use; contaminated products add salmonella/heavy-metal risk
- Extracts and shots deliver many times the leaf dose — see the kratom-extracts profile
✚Overdose signs
- Severe nausea/vomiting, sedation, slow breathing (especially combined with other depressants)
- Seizures have been reported with extracts — call poison control / emergency services
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Mitragynine (Kratom's Main Alkaloid) | Not federally scheduled | Dependence and withdrawal are real: daily use builds a habit with opioid-type withdrawal (restless legs, anxiety, cravings); Potentiates other sedatives; dangerous with alcohol, benzos and opioids | Pure powder is a research chemical |
| Heroin | Schedule I | Extremely addictive — physical dependence in weeks; Overdose: breathing slows or stops | ~$10–$40 per bag |
| Fentanyl | Schedule II | Respiratory depression; Addiction in days | ~$20–$40 per counterfeit pill |
| Fentanyl HCl (powder) | Schedule II / analogue prosecutions | Lab-purity powder is far stronger than street mixes; Weighing errors are fatal | ~$60–$120/gram wholesale equivalent |
| Acetylfentanyl | Schedule I | ~5–15× weaker than fentanyl but still deadly at gram-level mistakes; Frequent cause of cluster overdoses | ~$25–$60/g where found |
| Furanylfentanyl (Fu-F) | Schedule I | Linked to hundreds of fatal overdoses 2016–2018; Potency similar to fentanyl | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Mitragynine (Kratom's Main Alkaloid) look like?
Pure compound: white powder (research chemical). In practice it arrives inside leaf powder, capsules, shots and extracts
What are the signs of a Mitragynine (Kratom's Main Alkaloid) overdose?
Severe nausea/vomiting, sedation, slow breathing (especially combined with other depressants); Seizures have been reported with extracts — call poison control / emergency services Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.
How addictive is it?
Dependence and withdrawal are real: daily use builds a habit with opioid-type withdrawal (restless legs, anxiety, cravings) Dependence can develop with regular use.