Sedatives & Hypnotics
Combretum quadrangulare (Sakae Naa)
Street names: Sakae Naa, Combretum, Thai kratom alternative
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Mild opioid-receptor-adjacent calm and pain relief — Southeast Asian traditional use
⚠Key risks
- Essentially unresearched in humans
- Marketed as kratom substitute to evade kratom bans — same dependence pathway potential
- Product substitution: 'sakae naa' products testing as actual kratom or adulterated
✚Overdose signs
- Sedation
- Nausea
Category comparison — Sedatives & Hypnotics
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Combretum quadrangulare (Sakae Naa) | Unregulated herb; legal most places | Essentially unresearched in humans; Marketed as kratom substitute to evade kratom bans — same dependence pathway potential | $10–$25 per 50 g |
| Zolpidem (Ambien/Stilnox) | Schedule IV | Sleep-walking, sleep-driving, hallucinations; Dependence and rebound insomnia | ~$2–$10 per 10 mg tablet |
| Secobarbital (Seconal) | Schedule II | Barbiturates: tiny margin between dose and death; Fatal in overdose, brutal withdrawal (seizures) — replaced by benzos in medicine | ~$15–$40 per capsule where diverted |
| Carisoprodol (Soma) | Schedule IV | Converts to meprobamate (Miltown) — dependence; Popular 'Soma Coma' mix with opioids — deadly | ~$1–$8 per 350 mg tablet |
| Cyclobenzaprine (Flexeril) | Not scheduled | Overdose causes hallucinations, seizures, heart rhythm problems; Abuse usually in combination (potentiates opioids) | ~$1–$5 per 10 mg tablet |
| Pentobarbital (Nembutal) | Schedule II | Veterinary euthanasia drug — overdose is usually fatal; Narrow safety margin (barbiturate) | ~$30–$100+ per vial/capsule-equivalent |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Combretum quadrangulare (Sakae Naa) look like?
Dried leaves chewed or brewed; sold online as 'kratom alternative'
What are the signs of a Combretum quadrangulare (Sakae Naa) overdose?
Sedation; Nausea Call emergency services immediately.
How addictive is it?
Essentially unresearched in humans Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.