Opioids

Tapentadol (Nucynta)

Street names: Nucynta, Palexia, Tapal

Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines

⚡What it does

Opioid pain relief plus norepinephrine reuptake inhibition — tramadol's stronger cousin
Faster, more predictable than tramadol (no CYP2D6 lottery)

Substance	Class	Top risks	Street price
Tapentadol (Nucynta)	Schedule II	Schedule II for a reason: full mu-opioid addiction profile; Seizure risk lower than tramadol but present at high doses	~$1–$5 per tablet diverted
Heroin	Schedule I	Extremely addictive — physical dependence in weeks; Overdose: breathing slows or stops	~$10–$40 per bag
Fentanyl	Schedule II	Respiratory depression; Addiction in days	~$20–$40 per counterfeit pill
Fentanyl HCl (powder)	Schedule II / analogue prosecutions	Lab-purity powder is far stronger than street mixes; Weighing errors are fatal	~$60–$120/gram wholesale equivalent
Acetylfentanyl	Schedule I	~5–15× weaker than fentanyl but still deadly at gram-level mistakes; Frequent cause of cluster overdoses	~$25–$60/g where found
Furanylfentanyl (Fu-F)	Schedule I	Linked to hundreds of fatal overdoses 2016–2018; Potency similar to fentanyl	~$20–$50/g

Street prices are regional estimates. Potency and cuts vary constantly.

What does Tapentadol (Nucynta) look like?

50–250 mg tablets; ER versions

What are the signs of a Tapentadol (Nucynta) overdose?

Pinpoint pupils; Slow breathing; Sedation Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.

How addictive is it?

Schedule II for a reason: full mu-opioid addiction profile Dependence can develop with regular use.

Facts on this page are compiled from these primary sources. External links open in a new tab.