Psychedelics
5-MeO-DMT (Bufo / Toad Venom)
Street names: Bufo, Toad, The God Molecule, 5-MeO
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- 5–20 min COMPLETE dissolution: white light, ego death, 'becoming everything' — far stronger per mg than DMT
- Bufo retreats popular in Mexico/US
⚠Key risks
- RETREAT DEATHS: asphyxiation and aspiration — facilitators sometimes restrain or pour water on people mid-experience; several documented fatalities (2018–2025)
- NOT the same as DMT — bufotenin (5-HO) vs 5-MeO confusion matters; smoking raw toad secretions adds bufotenin load
- Deadly combined with MAOIs (harmalas/Syrian rue) — serotonin syndrome
- Psychological destabilization: panic, mania in the days after
- Toad populations stressed by 'milking'
✚Overdose signs
- Loss of consciousness with vomiting (aspiration risk)
- Panic/struggling during the peak
- Serotonin syndrome signs with MAOIs
📋Quick facts
Also known asBufo, Toad, The God Molecule, 5-MeO
CategoryPsychedelics
Schedule / classSchedule I (US); controlled most regions
AppearanceWhite powder (synthetic or extracted from Sonoran Desert toad glands); smoked/vaporized 5–20 mg
Street priceRetreat ceremonies $150–$500 per session; powder $50–$150/100 mg
Legal statusSchedule I US; Mexico tolerates retreats; toad species protected in some US states
Last updated2026-09-18
Sources: NIDA, EMCDDA, MAPS
Category comparison — Psychedelics
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| 5-MeO-DMT (Bufo / Toad Venom) | Schedule I | RETREAT DEATHS: asphyxiation and aspiration — facilitators sometimes restrain or pour water on people mid-experience; several documented fatalities (2018–2025); NOT the same as DMT — bufotenin (5-HO) vs 5-MeO confusion matters; smoking raw toad secretions adds bufotenin load | Retreat ceremonies $150–$500 per session |
| DMT (dimethyltryptamine) | Schedule I | Psychological distress ('bad trips'); Dangerous behavior if unprepared | ~$20–$60 per 50–100 mg dose |
| Yopo / Cebil (Anadenanthera Snuffs) | DMT/bufotenin controlled US; seeds legal to possess most places; Syrian rue | Syrian rue combination = MAOI — DEADLY with SSRIs and MDMA (serotonin syndrome); Severe nausea/pain at insufflation; mucosal damage from repeated snuffing | Seeds $10–$30 per 100 g |
| Ayahuasca (The Brew) | Schedule I components | THE DEADLY COMBINATION: vine MAOIs + antidepressants (SSRIs/SNRIs/MAOIs) or MDMA = serotonin syndrome — deaths documented at retreats; Hypertensive crisis with tyramine-containing foods (aged cheese, cured meats) around ceremonies | Retreats $500–$3,500 per week |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does 5-MeO-DMT (Bufo / Toad Venom) look like?
White powder (synthetic or extracted from Sonoran Desert toad glands); smoked/vaporized 5–20 mg
What are the signs of a 5-MeO-DMT (Bufo / Toad Venom) overdose?
Loss of consciousness with vomiting (aspiration risk); Panic/struggling during the peak; Serotonin syndrome signs with MAOIs Call emergency services immediately.
How addictive is it?
RETREAT DEATHS: asphyxiation and aspiration — facilitators sometimes restrain or pour water on people mid-experience; several documented fatalities (2018–2025) Dependence can develop with regular use.