Opioids
Isotonitazene ('Iso')
Street names: Iso, Isotonitazene, ITZ
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Nitazene-class opioid — fentanyl-comparable potency, long legs
⚠Key risks
- 2020–2022 US midwest wave; detected in counterfeit oxycodone and heroin
- Naloxone works — multiple doses
- Missed by standard screens
- Often found WITH fentanyl and xylazine in the same sample
✚Overdose signs
- Respiratory depression
- Cyanosis, unresponsive
- Re-sedation after naloxone
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Isotonitazene ('Iso') | Schedule I | 2020–2022 US midwest wave; detected in counterfeit oxycodone and heroin; Naloxone works — multiple doses | Contaminant/adulterant pricing |
| Heroin | Schedule I | Extremely addictive — physical dependence in weeks; Overdose: breathing slows or stops | ~$10–$40 per bag |
| Fentanyl | Schedule II | Respiratory depression; Addiction in days | ~$20–$40 per counterfeit pill |
| Fentanyl HCl (powder) | Schedule II / analogue prosecutions | Lab-purity powder is far stronger than street mixes; Weighing errors are fatal | ~$60–$120/gram wholesale equivalent |
| Acetylfentanyl | Schedule I | ~5–15× weaker than fentanyl but still deadly at gram-level mistakes; Frequent cause of cluster overdoses | ~$25–$60/g where found |
| Furanylfentanyl (Fu-F) | Schedule I | Linked to hundreds of fatal overdoses 2016–2018; Potency similar to fentanyl | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Isotonitazene ('Iso') look like?
Yellow/off-white powder; pressed into counterfeit pills
What are the signs of a Isotonitazene ('Iso') overdose?
Respiratory depression; Cyanosis, unresponsive; Re-sedation after naloxone Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.
How addictive is it?
2020–2022 US midwest wave; detected in counterfeit oxycodone and heroin Dependence can develop with regular use.