Opioids
Isotonitazene ('Iso')
Street names: Iso, Isotonitazene, ITZ
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Nitazene-class opioid — fentanyl-comparable potency, long legs
⚠Key risks
- 2020–2022 US midwest wave; detected in counterfeit oxycodone and heroin
- Naloxone works — multiple doses
- Missed by standard screens
- Often found WITH fentanyl and xylazine in the same sample
✚Overdose signs
- Respiratory depression
- Cyanosis, unresponsive
- Re-sedation after naloxone
📋Quick facts
Also known asIso, Isotonitazene, ITZ
CategoryOpioids
Schedule / classSchedule I (US, 2022)
AppearanceYellow/off-white powder; pressed into counterfeit pills
Street priceContaminant/adulterant pricing
Legal statusSchedule I US; controlled EU/UK/CA
Last updated2026-09-18
Sources: DEA, EMCDDA, NIDA
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Isotonitazene ('Iso') | Schedule I | 2020–2022 US midwest wave; detected in counterfeit oxycodone and heroin; Naloxone works — multiple doses | Contaminant/adulterant pricing |
| Etonitazene | Schedule I | ~10–25× fentanyl potency; Active at sub-milligram doses — nearly impossible to dose safely | ~$40–$100/g |
| Metonitazene | Schedule I | Drove 2021 US east-coast overdose waves; detected in 'dope' and counterfeit pills; Standard drug screens miss it — hospitals often don't know what reversed them | Mixed into bags — no separate street price |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Isotonitazene ('Iso') look like?
Yellow/off-white powder; pressed into counterfeit pills
What are the signs of a Isotonitazene ('Iso') overdose?
Respiratory depression; Cyanosis, unresponsive; Re-sedation after naloxone Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.
How addictive is it?
2020–2022 US midwest wave; detected in counterfeit oxycodone and heroin Dependence can develop with regular use.