Isotretinoin (Accutane)
Street names: Accutane, Roaccutane, Isotroin
⚡What it does
- The definitive cystic-acne cure — shrinks sebaceous glands permanently
- Often lifelong clearance after one course
⚠Key risks
- TERATOGENIC — severe birth defects; pregnancy tests + two contraception forms required
- Dry skin/lips/eyes (universal)
- Depression/suicidality association — debated but monitored
- Grey-market acne 'brands' skip the monitoring that makes it safe
✚Overdose signs
- No acute overdose
- Severe headache, vision changes (pseudotumor cerebri — emergency)
- Mood crisis
Category comparison — Performance & Grey-Market Pharma
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Isotretinoin (Accutane) | Rx-only with strict pregnancy-prevention programs | TERATOGENIC — severe birth defects; pregnancy tests + two contraception forms required; Dry skin/lips/eyes (universal) | ~$0.50–$2 per capsule grey-market |
| AICAR (Acadesine) | Unscheduled | No human safety data — cancer-risk flags in cell studies; Sold as research chemical, zero quality control | ~$50–$150 per gram |
| Clenbuterol HCl | Not approved for human use | Racing heart, arrhythmia, tremors; Overdose: dangerous potassium shifts, cardiac events | ~$0.50–$2 per 40 mcg tablet |
| Anastrozole (Arimidex) | Rx-only | Bone density loss, joint pain with long-term use; Crash estrogen too low → depression, libido loss | ~$2–$8 per 1 mg tablet |
| Liraglutide (Saxenda) | Rx-only — not a controlled drug | Sold grey-market at huge markups with counterfeit/refilled pens; Nausea, pancreatitis risk | ~$200–$500 per pen grey-market |
| Naltrexone–Bupropion (Contrave) | Rx-only — not controlled | Bupropion lowers seizure threshold; Misuse for stimulant-like effect is possible but weak | ~$1–$4 per tablet grey-market |
RxBrand names on the grey market
These brands are sold as this compound. Same molecule, different label and supply chain — quality varies enormously between them.
?Frequently asked questions
What does Isotretinoin (Accutane) look like?
10/20/40 mg soft capsules; many generic brands
What are the signs of a Isotretinoin (Accutane) overdose?
No acute overdose; Severe headache, vision changes (pseudotumor cerebri — emergency); Mood crisis Call emergency services immediately.
How addictive is it?
TERATOGENIC — severe birth defects; pregnancy tests + two contraception forms required Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.