Weight Loss & Metabolic Meds
Retatrutide ('Reta')
Street names: Reta, LY3437943, Triple G, Retatrutide acetate
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Triple agonist (GIP + GLP-1 + glucagon) — trial results through 2025 show weight loss up to ~28–30% of body weight, the largest effect ever recorded for an obesity drug
- Strong appetite suppression and altered food preference
- Not a finished medicine — everything sold today is experimental powder dosed by guesswork
⚠Key risks
- The most-searched grey-market peptide of 2025–26 — demand outran the clinical trial program within a year
- Zero quality control: vial contents range from underdosed to contaminated; independent tests of grey-market 'reta' have found wrong peptides and endotoxins
- Rodent studies of the class flag thyroid C-cell tumors — the human relevance is unknown because the drug is still being studied
- Heart-rate increase, GI distress, gallbladder events — monitored in trials, invisible on the grey market
- Self-injection without medical supervision: infection, dosing errors, and no one to call when something goes wrong
✚Overdose signs
- Persistent vomiting/diarrhea with signs of dehydration
- Racing or irregular heartbeat at rest
- Lump or hoarseness that persists (thyroid warning sign — see a doctor)
Category comparison — Weight Loss & Metabolic Meds
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Retatrutide ('Reta') | Investigational — not approved anywhere as of 2026; in Phase 3 trials; grey-market sale is unregulated | The most-searched grey-market peptide of 2025–26 — demand outran the clinical trial program within a year; Zero quality control: vial contents range from underdosed to contaminated; independent tests of grey-market 'reta' have found wrong peptides and endotoxins | ~$150–400 per month of grey-market vials |
| Liothyronine (T3) | Rx-only — not controlled | At abuse doses: cardiac arrhythmia, heart failure, bone loss; Muscle catabolism — the 'cut' comes with your muscle | ~$0.50–$2 per tablet grey-market |
| Levothyroxine (T4) | Rx-only — not controlled | Overtreatment = hyperthyroid state: palpitations, anxiety, bone loss; Taking it without hypothyroidism provides little benefit at real risk | ~$0.10–$0.50 per tablet |
| Orlistat (Xenical/Alli) | OTC | Oily stools, urgency, flatulence — the famous GI sides if you eat fatty; Fat-soluble vitamin absorption drops (take a multivitamin) | ~$0.50–$2 per capsule |
| Sibutramine (Meridia) | Withdrawn | WITHDRAWN worldwide for cardiovascular events (strokes, heart attacks in the SCOUT trial); Survives in adulterated supplements — buyers don't know they're taking it | ~$0.50–$2 per capsule illicit |
| Metformin | Rx-only — not controlled | GI upset (diarrhea, nausea) — titrate slowly; Lactic acidosis — rare, dangerous, mostly in kidney disease | ~$0.05–$0.30 per tablet |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Retatrutide ('Reta') look like?
Grey-market: lyophilized (freeze-dried) powder in vials, sold with bacteriostatic water for self-injection; no legitimate consumer product exists
What are the signs of a Retatrutide ('Reta') overdose?
Persistent vomiting/diarrhea with signs of dehydration; Racing or irregular heartbeat at rest; Lump or hoarseness that persists (thyroid warning sign — see a doctor) Call emergency services immediately.
How addictive is it?
The most-searched grey-market peptide of 2025–26 — demand outran the clinical trial program within a year Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.