Weight Loss & Metabolic Meds
Synephrine (Bitter Orange)
Street names: Bitter orange, p-Synephrine, Citrus aurantium
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Mild ephedra-like stimulation
- Appetite suppression
⚠Key risks
- Replaced ephedra after its ban — heart-attack and stroke case reports followed
- Stacked with caffeine the blood-pressure spike multiplies
- Dose on the label is often wrong
✚Overdose signs
- Chest pain, pounding heart
- Headache, high blood pressure
- Anxiety, tremor
Category comparison — Weight Loss & Metabolic Meds
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Synephrine (Bitter Orange) | Legal supplement; banned by WADA-adjacent lists in sport | Replaced ephedra after its ban — heart-attack and stroke case reports followed; Stacked with caffeine the blood-pressure spike multiplies | ~$15–$40 per bottle |
| Liothyronine (T3) | Rx-only — not controlled | At abuse doses: cardiac arrhythmia, heart failure, bone loss; Muscle catabolism — the 'cut' comes with your muscle | ~$0.50–$2 per tablet grey-market |
| Levothyroxine (T4) | Rx-only — not controlled | Overtreatment = hyperthyroid state: palpitations, anxiety, bone loss; Taking it without hypothyroidism provides little benefit at real risk | ~$0.10–$0.50 per tablet |
| Orlistat (Xenical/Alli) | OTC | Oily stools, urgency, flatulence — the famous GI sides if you eat fatty; Fat-soluble vitamin absorption drops (take a multivitamin) | ~$0.50–$2 per capsule |
| Sibutramine (Meridia) | Withdrawn | WITHDRAWN worldwide for cardiovascular events (strokes, heart attacks in the SCOUT trial); Survives in adulterated supplements — buyers don't know they're taking it | ~$0.50–$2 per capsule illicit |
| Metformin | Rx-only — not controlled | GI upset (diarrhea, nausea) — titrate slowly; Lactic acidosis — rare, dangerous, mostly in kidney disease | ~$0.05–$0.30 per tablet |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Synephrine (Bitter Orange) look like?
Fat-burner and pre-workout ingredient, often stacked with caffeine
What are the signs of a Synephrine (Bitter Orange) overdose?
Chest pain, pounding heart; Headache, high blood pressure; Anxiety, tremor Call emergency services immediately.
How addictive is it?
Replaced ephedra after its ban — heart-attack and stroke case reports followed Dependence can develop with regular use.