Weight Loss & Metabolic Meds
Tesofensine
Street names: tesofensine, NS2330
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Strong appetite suppression
- Notable weight loss in trials (~10% at higher doses)
- Stimulant-like wakefulness
⚠Key risks
- Never approved anywhere
- Raised heart rate and blood pressure in trials
- Unknown long-term safety
- Grey-market products have no quality control
- Originally developed for Parkinson's and Alzheimer's — abandoned
✚Overdose signs
- Racing heart
- High blood pressure
- Agitation
- Insomnia
Category comparison — Weight Loss & Metabolic Meds
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Tesofensine | Unapproved | Never approved anywhere; Raised heart rate and blood pressure in trials | Roughly €50-100 per month from online peptide and research-chemical shops. |
| Liothyronine (T3) | Rx-only — not controlled | At abuse doses: cardiac arrhythmia, heart failure, bone loss; Muscle catabolism — the 'cut' comes with your muscle | ~$0.50–$2 per tablet grey-market |
| Levothyroxine (T4) | Rx-only — not controlled | Overtreatment = hyperthyroid state: palpitations, anxiety, bone loss; Taking it without hypothyroidism provides little benefit at real risk | ~$0.10–$0.50 per tablet |
| Orlistat (Xenical/Alli) | OTC | Oily stools, urgency, flatulence — the famous GI sides if you eat fatty; Fat-soluble vitamin absorption drops (take a multivitamin) | ~$0.50–$2 per capsule |
| Sibutramine (Meridia) | Withdrawn | WITHDRAWN worldwide for cardiovascular events (strokes, heart attacks in the SCOUT trial); Survives in adulterated supplements — buyers don't know they're taking it | ~$0.50–$2 per capsule illicit |
| Metformin | Rx-only — not controlled | GI upset (diarrhea, nausea) — titrate slowly; Lactic acidosis — rare, dangerous, mostly in kidney disease | ~$0.05–$0.30 per tablet |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Tesofensine look like?
Capsules or powder sold by grey-market 'research chemical' and peptide vendors.
What are the signs of a Tesofensine overdose?
Racing heart; High blood pressure; Agitation Call emergency services immediately.
How addictive is it?
Never approved anywhere Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.