Psychedelics
Yopo / Cebil (Anadenanthera Snuffs)
Street names: Yopo, Cebil, Vilca, Cojoba, Syrian rue partner
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Short 30–60 min intense tryptamine snuff experience (bufotenin/5-MeO-DMT/DMT mix)
- Traditional Caribbean/South American shamanic use
⚠Key risks
- Syrian rue combination = MAOI — DEADLY with SSRIs and MDMA (serotonin syndrome)
- Severe nausea/pain at insufflation; mucosal damage from repeated snuffing
- Little modern safety data; traditional preparations were purified by skilled practitioners
- Bufotenin-loaded snuffs are harsh and unpredictable
✚Overdose signs
- Serotonin syndrome signs with MAOIs
- Severe vomiting, collapse
- Extreme cardiovascular stress
📋Quick facts
Also known asYopo, Cebil, Vilca, Cojoba, Syrian rue partner
CategoryPsychedelics
Schedule / classDMT/bufotenin controlled US; seeds legal to possess most places; Syrian rue (MAOI) restricted some EU
AppearanceToasted and ground seeds of Anadenanthera peregrina/colubrina, snuffed; combined with Syrian rue (Peganum harmala) in modern use
Street priceSeeds $10–$30 per 100 g; rue seeds $5–$15
Legal statusSeeds uncontrolled US; active tryptamines Schedule I; harmala alkaloids restricted DE/others
Last updated2026-09-18
Sources: NIDA, EMCDDA, Erowid
Category comparison — Psychedelics
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Yopo / Cebil (Anadenanthera Snuffs) | DMT/bufotenin controlled US; seeds legal to possess most places; Syrian rue | Syrian rue combination = MAOI — DEADLY with SSRIs and MDMA (serotonin syndrome); Severe nausea/pain at insufflation; mucosal damage from repeated snuffing | Seeds $10–$30 per 100 g |
| 5-MeO-DMT (Bufo / Toad Venom) | Schedule I | RETREAT DEATHS: asphyxiation and aspiration — facilitators sometimes restrain or pour water on people mid-experience; several documented fatalities (2018–2025); NOT the same as DMT — bufotenin (5-HO) vs 5-MeO confusion matters; smoking raw toad secretions adds bufotenin load | Retreat ceremonies $150–$500 per session |
| DMT (dimethyltryptamine) | Schedule I | Psychological distress ('bad trips'); Dangerous behavior if unprepared | ~$20–$60 per 50–100 mg dose |
| Ayahuasca (The Brew) | Schedule I components | THE DEADLY COMBINATION: vine MAOIs + antidepressants (SSRIs/SNRIs/MAOIs) or MDMA = serotonin syndrome — deaths documented at retreats; Hypertensive crisis with tyramine-containing foods (aged cheese, cured meats) around ceremonies | Retreats $500–$3,500 per week |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Yopo / Cebil (Anadenanthera Snuffs) look like?
Toasted and ground seeds of Anadenanthera peregrina/colubrina, snuffed; combined with Syrian rue (Peganum harmala) in modern use
What are the signs of a Yopo / Cebil (Anadenanthera Snuffs) overdose?
Serotonin syndrome signs with MAOIs; Severe vomiting, collapse; Extreme cardiovascular stress Call emergency services immediately.
How addictive is it?
Syrian rue combination = MAOI — DEADLY with SSRIs and MDMA (serotonin syndrome) Dependence can develop with regular use.