Sedantes e hipnóticos
MAOIs (Phenelzine, Tranylcypromine, Moclobemide)
Street names: Nardil, Parnate, Phenelzine, Tranylcypromine, Moclobemide, Marplan
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Los antidepresivos más potentes para la depresión atípica - inhibición irreversible (Nardil / Parnate) o reversible (moclobemide) de la monoamina oxidasa
⚠Key risks
- CRISIS DE TYRAMINA: queso envejecido, carnes curadas, cerveza, soja fermentada → crisis hipertensiva (BP de nivel de ictus) – la interacción clásica
- SÍNDROME DE SEROTONINA con SSRI, MDMA, tramadol, dextromethorphan, hierba de San Juan — potencialmente fatal; sin reglas (2 semanas para irreversibles)
- La razón por la cual 'meperidina + MAOI' es una combinación letal (encuesta buscada)
- Insomnio, aumento de peso, orthostasis
- Sub-prescritos por miedo, pero herramientas reales con reglas reales
✚Overdose signs
- Dolor de cabeza severo, BP pico (tiramina)
- Agitación, clon, fiebre (serotonina)
- Cambios de conciencia
Comparación de categoría — Sedantes e hipnóticos
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| MAOIs (Phenelzine, Tranylcypromine, Moclobemide) | Rx-only — not controlled | TYRAMINE CRISIS: aged cheese, cured meats, tap beer, fermented soy → hypertensive crisis (stroke-level BP) — the classic interaction; SEROTONIN SYNDROME with SSRIs, MDMA, tramadol, dextromethorphan, St John's Wort — potentially fatal; washout rules (2 weeks for irreversibles) | ~$0.50–$2 per tablet |
| Zolpidem (Ambien/Stilnox) | Schedule IV | Sleep-walking, sleep-driving, hallucinations; Dependence and rebound insomnia | ~$2–$10 per 10 mg tablet |
| Secobarbital (Seconal) | Schedule II | Barbiturates: tiny margin between dose and death; Fatal in overdose, brutal withdrawal (seizures) — replaced by benzos in medicine | ~$15–$40 per capsule where diverted |
| Carisoprodol (Soma) | Schedule IV | Converts to meprobamate (Miltown) — dependence; Popular 'Soma Coma' mix with opioids — deadly | ~$1–$8 per 350 mg tablet |
| Cyclobenzaprine (Flexeril) | Not scheduled | Overdose causes hallucinations, seizures, heart rhythm problems; Abuse usually in combination (potentiates opioids) | ~$1–$5 per 10 mg tablet |
| Pentobarbital (Nembutal) | Schedule II | Veterinary euthanasia drug — overdose is usually fatal; Narrow safety margin (barbiturate) | ~$30–$100+ per vial/capsule-equivalent |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does MAOIs (Phenelzine, Tranylcypromine, Moclobemide) look like?
Comprimidos (15 mg de fenelzina, 10 mg de tranylcypromina, 150-600 mg de moclobemida)
What are the signs of a MAOIs (Phenelzine, Tranylcypromine, Moclobemide) overdose?
Dolor de cabeza severo, BP pico (tiramina); Agitación, clon, fiebre (serotonina); Cambios de conciencia Call emergency services immediately.
How addictive is it?
CRISIS DE TYRAMINA: queso envejecido, carnes curadas, cerveza, soja fermentada → crisis hipertensiva (BP de nivel de ictus) – la interacción clásica Dependence can develop with regular use.