Opioids
N-Pyrrolidino Isotonitazene (NPI)
Street names: NPI, N-pyrro iso, Pyro isotonitazene
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Nitazene-class opioid — fentanyl-comparable potency
- Sedation, heavy euphoria, 'nod'
- Long duration vs fentanyl (4–8 h)
⚠Key risks
- THE most-reported new opioid in 2024 — detected in 10 countries (UNODC EWA)
- Active in the low-milligram range — dosing errors are fatal
- Missed by many standard immunoassay screens
- Frequently co-detected with xylazine/medetomidine in the same sample
✚Overdose signs
- Respiratory depression
- Pinpoint pupils, unresponsive
- Re-sedation after naloxone wears off
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| N-Pyrrolidino Isotonitazene (NPI) | Not scheduled federally | THE most-reported new opioid in 2024 — detected in 10 countries (UNODC EWA); Active in the low-milligram range — dosing errors are fatal | Sold as counterfeit pills |
| Heroin | Schedule I | Extremely addictive — physical dependence in weeks; Overdose: breathing slows or stops | ~$10–$40 per bag |
| Fentanyl | Schedule II | Respiratory depression; Addiction in days | ~$20–$40 per counterfeit pill |
| Fentanyl HCl (powder) | Schedule II / analogue prosecutions | Lab-purity powder is far stronger than street mixes; Weighing errors are fatal | ~$60–$120/gram wholesale equivalent |
| Acetylfentanyl | Schedule I | ~5–15× weaker than fentanyl but still deadly at gram-level mistakes; Frequent cause of cluster overdoses | ~$25–$60/g where found |
| Furanylfentanyl (Fu-F) | Schedule I | Linked to hundreds of fatal overdoses 2016–2018; Potency similar to fentanyl | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does N-Pyrrolidino Isotonitazene (NPI) look like?
Off-white to beige powder; pressed into counterfeit oxycodone and 'M30' pills
What are the signs of a N-Pyrrolidino Isotonitazene (NPI) overdose?
Respiratory depression; Pinpoint pupils, unresponsive; Re-sedation after naloxone wears off Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.
How addictive is it?
THE most-reported new opioid in 2024 — detected in 10 countries (UNODC EWA) Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.