Performance & Grey-Market Pharma
St John's Wort (Hypericum)
Street names: SJW, Hypericum perforatum, Amber, Klamath weed
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Mild antidepressant effect for mild-moderate depression (German Rx tradition)
- The most-studied herbal psychotropic
⚠Key risks
- THE INTERACTION KING: induces CYP3A4 and P-gp — weakens oral contraceptives (pregnancies documented), HIV antiretrovirals, transplant immunosuppressants, blood thinners, chemotherapy
- Serotonin syndrome with SSRIs, MDMA, tramadol
- Photosensitivity (livestock poisoning history)
- The 'natural so safe' assumption is the danger — it is a real psychotropic with real pharmacology
✚Overdose signs
- Serotonin syndrome signs with combos
- Severe photosensitivity reactions
Category comparison — Performance & Grey-Market Pharma
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| St John's Wort (Hypericum) | OTC supplement — unregulated US; Rx-only Germany for depression | THE INTERACTION KING: induces CYP3A4 and P-gp — weakens oral contraceptives (pregnancies documented), HIV antiretrovirals, transplant immunosuppressants, blood thinners, chemotherapy; Serotonin syndrome with SSRIs, MDMA, tramadol | $8–$20 per bottle |
| AICAR (Acadesine) | Unscheduled | No human safety data — cancer-risk flags in cell studies; Sold as research chemical, zero quality control | ~$50–$150 per gram |
| Clenbuterol HCl | Not approved for human use | Racing heart, arrhythmia, tremors; Overdose: dangerous potassium shifts, cardiac events | ~$0.50–$2 per 40 mcg tablet |
| Anastrozole (Arimidex) | Rx-only | Bone density loss, joint pain with long-term use; Crash estrogen too low → depression, libido loss | ~$2–$8 per 1 mg tablet |
| Liraglutide (Saxenda) | Rx-only — not a controlled drug | Sold grey-market at huge markups with counterfeit/refilled pens; Nausea, pancreatitis risk | ~$200–$500 per pen grey-market |
| Naltrexone–Bupropion (Contrave) | Rx-only — not controlled | Bupropion lowers seizure threshold; Misuse for stimulant-like effect is possible but weak | ~$1–$4 per tablet grey-market |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does St John's Wort (Hypericum) look like?
Yellow-flowered herb; capsules, teas, tinctures standardized to hypericin/hyperforin
What are the signs of a St John's Wort (Hypericum) overdose?
Serotonin syndrome signs with combos; Severe photosensitivity reactions Call emergency services immediately.
How addictive is it?
THE INTERACTION KING: induces CYP3A4 and P-gp — weakens oral contraceptives (pregnancies documented), HIV antiretrovirals, transplant immunosuppressants, blood thinners, chemotherapy Dependence can develop with regular use.