Opioids
Protodesnitazene
Street names: Proto-desnitro, PDN
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Desnitro nitazene — opioid effects, generally weaker than parent nitazenes but unpredictable
- Sedation, euphoria
⚠Key risks
- THE most-reported new psychoactive substance of 2025 — first detections in 4 countries (UNODC EWA)
- Desnitro analogues can re-nitrosate into more potent compounds
- Unknown pharmacology in humans — no safety data exists
- Signals continued nitazene supply-chain evolution after law-enforcement pressure
✚Overdose signs
- Respiratory depression
- Pinpoint pupils
- Sedation out of proportion to the dose
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Protodesnitazene | Not scheduled | THE most-reported new psychoactive substance of 2025 — first detections in 4 countries (UNODC EWA); Desnitro analogues can re-nitrosate into more potent compounds | Precursor/wholesale pricing |
| Heroin | Schedule I | Extremely addictive — physical dependence in weeks; Overdose: breathing slows or stops | ~$10–$40 per bag |
| Fentanyl | Schedule II | Respiratory depression; Addiction in days | ~$20–$40 per counterfeit pill |
| Fentanyl HCl (powder) | Schedule II / analogue prosecutions | Lab-purity powder is far stronger than street mixes; Weighing errors are fatal | ~$60–$120/gram wholesale equivalent |
| Acetylfentanyl | Schedule I | ~5–15× weaker than fentanyl but still deadly at gram-level mistakes; Frequent cause of cluster overdoses | ~$25–$60/g where found |
| Furanylfentanyl (Fu-F) | Schedule I | Linked to hundreds of fatal overdoses 2016–2018; Potency similar to fentanyl | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly.
?Frequently asked questions
What does Protodesnitazene look like?
Off-white powder; identified as both a precursor and a street opioid
What are the signs of a Protodesnitazene overdose?
Respiratory depression; Pinpoint pupils; Sedation out of proportion to the dose Call emergency services immediately and give naloxone if available — it reverses opioid overdoses.
How addictive is it?
THE most-reported new psychoactive substance of 2025 — first detections in 4 countries (UNODC EWA) Dependence can develop with regular use.
🔗Sources & further reading
Facts on this page are compiled from these primary sources. External links open in a new tab.